MATHEMATICAL MODELING OF COHESION ENERGY FOR CORONA VIRUS PARTICLES IN HUMAN BLOOD CELL USING THERMODYNAMIC CONTACT ANGLE APPROACH

Abstract

The uniqueness of the corona virus microbiological pathways has necessitated the need for a
mathematical model to predict its surface interaction with human blood cells which can serve as a
proactive measure in the understanding of the virus and the development of the vaccine. It is
clear from this study that the interaction between virus and the host cell during the first step of
virus-host encounter is not just limited to the hospitality of the host cells to the virus resulting in
cellular binding and entry. Virus-host interaction is a two way dialogue in which the virus takes
advantage of the host cells owned signal transduction system to transmit signals to the cells. The
model so develop can make use of so many probe liquids like water with surface tension of 72.8
dyn/cm, glycerin at surface tension of 63.4 dyn/cm, olive oil with surface tension 32 dyn/cm. This
model can be extended to other viral infection such as herpes simplex virus, hepatitis c virus and
so on for the determination of their surface interaction energies with the human blood cells so
long as the contact angle has been determined experimentally.